NOTCH3
notch 3
Synonyms:
CADASIL, CASIL, IMF2
Species:
Human NOTCH3 (4854), Mouse Notch3 (18131), Rat Notch3 (56761), Zebrafish notch3 (58066), dog NOTCH3 (610439), domestic cat NOTCH3 (101088469), cow NOTCH3 (789485), sheep NOTCH3 (101123554), domestic guinea pig Notch3 (100716867), naked mole-rat Notch3 (101722220)
UniProtKB ID:
Gene ID:
- Human(4854) Summary: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
- Mouse(18131) notch 3
- Rat(56761) notch 3
- Zebrafish(58066) notch homolog 3
- dog(610439) notch 3
- domestic cat(101088469) notch 3
- cow(789485) notch 3
- sheep(101123554) notch 3
- domestic guinea pig(100716867) notch 3
- naked mole-rat(101722220) notch 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NOTCH 3/N3ECD Antibody, clone 1E4, clone 1E4, 1 mg/mL, from mouse,
Species Reactivity
human
Application
electron microscopy
immunocytochemistry
western blot
immunocytochemistry
western blot
Monoclonal Anti-NOTCH3 antibody produced in mouse, clone 2E2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-Notch3 antibody, Rat monoclonal, purified from hybridoma cell culture,
Species Reactivity
human, rat
Application
western blot