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Merck

NLRP7

NLR family, pyrin domain containing 7

Synonyms:
CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3
Species:
Human NLRP7 (199713), cow NLRP7 (100336623), domestic cat NLRP7 (101094063), cow NLRP7 (100301263)
UniProtKB ID:
Q8WX94, E9PE16, Q32MH8, Q7RTR1
Gene ID:
  • Human(199713) Summary: This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • cow(100336623) NLR family, pyrin domain containing 7
  • domestic cat(101094063) NLR family, pyrin domain containing 7
  • cow(100301263) NLR family, pyrin domain containing 7

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