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Merck

MDM2

MDM2 oncogene, E3 ubiquitin protein ligase

Synonyms:
ACTFS, HDMX, hdm2
Species:
Human MDM2 (4193), Mouse Mdm2 (17246), Rat Mdm2 (314856), Zebrafish mdm2 (30637), dog MDM2 (403693), domestic cat MDM2 (493939), cow MDM2 (540378), Horse MDM2 (100033891), chicken MDM2 (395609), domestic guinea pig Mdm2 (100724684) ...More
UniProtKB ID:
Q00987, A6NL51, A8K2S6, Q13226, Q13297, Q13298, Q13299, Q13300
Gene ID:
  • Human(4193) Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
  • Mouse(17246) transformed mouse 3T3 cell double minute 2
  • Rat(314856) p53 E3 ubiquitin protein ligase
  • Zebrafish(30637) transformed 3T3 cell double minute 2 homolog (mouse)
  • dog(403693) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • domestic cat(493939) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • cow(540378) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • Horse(100033891) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • chicken(395609) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • domestic guinea pig(100724684) MDM2 oncogene, E3 ubiquitin protein ligase
  • naked mole-rat(101724821) MDM2 oncogene, E3 ubiquitin protein ligase
  • sheep(101104979) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4501849
Anti-MDM2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
western blot
SAB4300284
Anti-phospho-MDM2 (pSer166) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
SAB4503937
Anti-phospho-MDM2 (pSer166) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB4300601
Anti-MDM2 (Ab-166) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
OP145
Anti-MDM2 (Ab-5) Mouse mAb (4B2C1.11), liquid, clone 4B2C1.11, Calbiochem®,
Species Reactivity
human
Application

Proteins

Product Number
Description
Species
SRP2095
MDM2, HIS tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE), buffered aqueous solution,
Species
human
M0321
MDM2, GST-tagged human, recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
EHU098571
MISSION® esiRNA, targeting human MDM2,
Species
human