MBP
myelin basic protein
Synonyms:
Species:
Human MBP (4155), Mouse Mbp (17196), Rat Mbp (24547), chicken MBP (396217), domestic cat MBP (101096421), dog MBP (476160), cow MBP (618684), naked mole-rat Mbp (101702488), domestic guinea pig Mbp (100731253), sheep MBP (101109407)
UniProtKB ID:
Gene ID:
- Human(4155) Summary: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
- Mouse(17196) myelin basic protein
- Rat(24547) myelin basic protein
- chicken(396217) myelin basic protein
- domestic cat(101096421) myelin basic protein
- dog(476160) myelin basic protein
- cow(618684) myelin basic protein
- naked mole-rat(101702488) myelin basic protein
- domestic guinea pig(100731253) myelin basic protein
- sheep(101109407) myelin basic protein
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MBP antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Myelin Basic Protein Mouse mAb (SMI-99), liquid, clone SMI-99, Calbiochem®,
Species Reactivity
guinea pig, mammals
Application
Anti-MBP, affinity isolated antibody,
Species Reactivity
dog, guinea pig, horse, human, rabbit, rat
Application
western blot
Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat, clone 14, tissue culture supernatant,
Species Reactivity
chicken, horse, human
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Anti-phospho-MBP Antibody, clone P12, clone P12, Upstate®, from mouse,
Species Reactivity
vertebrates
Application
activity assay
western blot
western blot
Proteins
Product Number
Description
Species
Myelin Basic Protein bovine, ≥90% (SDS-PAGE), lyophilized powder, suitable for activity assay,
Species
cow
MBP, GST tagged human, recombinant, expressed in E. coli, ≥65% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
Myelin Basic Protein from guinea pig brain, ≥80% (SDS-PAGE), lyophilized powder, from guinea pig brain,
Species
domestic guinea pig