IL6ST
interleukin 6 signal transducer (gp130, oncostatin M receptor)
Synonyms:
CD130, CDW130, GP130, IL-6RB
Species:
Human IL6ST (3572), Mouse Il6st (16195), Rat Il6st (25205), Zebrafish il6st (100006778), chicken IL6ST (395684), dog IL6ST (403545), Horse IL6ST (100051700), cow IL6ST (522155), domestic cat IL6ST (101089832), sheep IL6ST (101113174) ...More
UniProtKB ID:
Gene ID:
- Human(3572) Summary: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010]
- Mouse(16195) interleukin 6 signal transducer
- Rat(25205) interleukin 6 signal transducer
- Zebrafish(100006778) interleukin 6 signal transducer
- chicken(395684) interleukin 6 signal transducer (gp130, oncostatin M receptor)
- dog(403545) interleukin 6 signal transducer (gp130, oncostatin M receptor)
- Horse(100051700) interleukin 6 signal transducer (gp130, oncostatin M receptor)
- cow(522155) interleukin 6 signal transducer (gp130, oncostatin M receptor)
- domestic cat(101089832) interleukin 6 signal transducer (gp130, oncostatin M receptor)
- sheep(101113174) interleukin 6 signal transducer (gp130, oncostatin M receptor)
- Domestic Rabbit(100349330) interleukin 6 signal transducer (gp130, oncostatin M receptor)
- naked mole-rat(101703833) interleukin 6 signal transducer (gp130, oncostatin M receptor)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CD130 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot