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Merck

IL37

interleukin 37

Synonyms:
FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
Species:
UniProtKB ID:
Gene ID:
  • Human(27178) Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • cow(786493) interleukin 37
  • dog(100686057) interleukin 37
  • domestic guinea pig(101788929) interleukin 37
  • naked mole-rat(101724994) interleukin 37
  • sheep(101111617) interleukin 37

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