IL21R
interleukin 21 receptor
Synonyms:
CD360, NILR
Species:
Human IL21R (50615), Mouse Il21r (60504), Rat Il21r (308977), Zebrafish il21r (100134976), cow IL21R (617967), Horse IL21R (100066814), domestic cat IL21R (101096026), dog IL21R (608011), chicken IL21R (416586), domestic guinea pig Il21r (100721842) ...More
UniProtKB ID:
Gene ID:
- Human(50615) Summary: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
- Mouse(60504) interleukin 21 receptor
- Rat(308977) interleukin 21 receptor
- Zebrafish(100134976) interleukin 21 receptor
- cow(617967) interleukin 21 receptor
- Horse(100066814) interleukin 21 receptor
- domestic cat(101096026) interleukin 21 receptor
- dog(608011) interleukin 21 receptor
- chicken(416586) interleukin 21 receptor
- domestic guinea pig(100721842) interleukin 21 receptor
- naked mole-rat(101701307) interleukin 21 receptor
- sheep(100820753) interleukin 21 receptor
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.