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Merck

IDH3A

isocitrate dehydrogenase 3 (NAD+) alpha

Synonyms:
Species:
Human IDH3A (3419), Mouse Idh3a (67834), Rat Idh3a (114096), sheep IDH3A (101120868), domestic guinea pig Idh3a (100720114), naked mole-rat Idh3a (101706503), Zebrafish idh3a (393926), cow IDH3A (282446), domestic cat IDH3A (101085721), dog IDH3A (479066)
UniProtKB ID:
P50213, D3DW83, Q9H3X0
Gene ID:
  • Human(3419) Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
  • Mouse(67834) isocitrate dehydrogenase 3 (NAD+) alpha
  • Rat(114096) isocitrate dehydrogenase 3 (NAD+) alpha
  • sheep(101120868) isocitrate dehydrogenase 3 (NAD+) alpha
  • domestic guinea pig(100720114) isocitrate dehydrogenase 3 (NAD+) alpha
  • naked mole-rat(101706503) isocitrate dehydrogenase 3 (NAD+) alpha
  • Zebrafish(393926) isocitrate dehydrogenase 3 (NAD+) alpha
  • cow(282446) isocitrate dehydrogenase 3 (NAD+) alpha
  • domestic cat(101085721) isocitrate dehydrogenase 3 (NAD+) alpha
  • dog(479066) isocitrate dehydrogenase 3 (NAD+) alpha
  • chicken(415362) isocitrate dehydrogenase 3 (NAD+) alpha

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2501692
Anti-IDH3A (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, mouse, pig, rat
Application
ELISA
western blot

Small Molecule - Cofactor

Product Number
Description
Species
20-221
NAD Cofactor, Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.,
Species
human