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Merck

GUCA1A

guanylate cyclase activator 1A (retina)

Synonyms:
C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1, dJ139D8.6
Species:
Human GUCA1A (2978), Mouse Guca1a (14913), Rat Guca1a (301233), Zebrafish guca1a (140430), chicken GUCA1A (374216), dog GUCA1A (609180), cow GUCA1A (282243), domestic cat GUCA1A (101080382), domestic guinea pig Guca1a (100715154), naked mole-rat Guca1a (101706235)
UniProtKB ID:
P43080, B3KWT4, Q7Z6T1, Q9NU14
Gene ID:
  • Human(2978) Summary: This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009]
  • Mouse(14913) guanylate cyclase activator 1a (retina)
  • Rat(301233) guanylate cyclase activator 1a (retina)
  • Zebrafish(140430) guanylate cyclase activator 1A
  • chicken(374216) guanylate cyclase activator 1A (retina)
  • dog(609180) guanylate cyclase activator 1A (retina)
  • cow(282243) guanylate cyclase activator 1A (retina)
  • domestic cat(101080382) guanylate cyclase activator 1A (retina)
  • domestic guinea pig(100715154) guanylate cyclase activator 1A (retina)
  • naked mole-rat(101706235) guanylate cyclase activator 1A (retina)
  • sheep(101108346) guanylate cyclase activator 1A (retina)

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