ERCC5
excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms:
COFS3, ERCM2, UVDR, XPG, XPGC
Species:
Human ERCC5 (2073), Mouse Ercc5 (22592), Rat Ercc5 (301382), domestic guinea pig Ercc5 (100734193), naked mole-rat Ercc5 (101723410), sheep ERCC5 (101114031), Domestic Rabbit ERCC5 (100338146), Zebrafish ercc5 (541502), cow ERCC5 (509602), Horse ERCC5 (100063431) ...More
UniProtKB ID:
Gene ID:
- Human(2073) Summary: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]
- Mouse(22592) excision repair cross-complementing rodent repair deficiency, complementation group 5
- Rat(301382) excision repair cross-complementing rodent repair deficiency, complementation group 5
- domestic guinea pig(100734193) excision repair cross-complementing rodent repair deficiency, complementation group 5
- naked mole-rat(101723410) excision repair cross-complementing rodent repair deficiency, complementation group 5
- sheep(101114031) excision repair cross-complementing rodent repair deficiency, complementation group 5
- Domestic Rabbit(100338146) excision repair cross-complementing rodent repair deficiency, complementation group 5
- Zebrafish(541502) excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))
- cow(509602) excision repair cross-complementing rodent repair deficiency, complementation group 5
- Horse(100063431) excision repair cross-complementing rodent repair deficiency, complementation group 5
- domestic cat(101085685) excision repair cross-complementing rodent repair deficiency, complementation group 5
- dog(485540) excision repair cross-complementing rodent repair deficiency, complementation group 5
- chicken(428019) excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-XPG (C-terminal) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot