EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms:
EIF2AK1, PKR, PRKR
Species:
Human EIF2AK2 (5610), Mouse Eif2ak2 (19106), Rat Eif2ak2 (54287), Zebrafish eif2ak2 (100001092), cow EIF2AK2 (347700), Horse EIF2AK2 (100147679), domestic cat EIF2AK2 (101082744), dog EIF2AK2 (611397), chicken EIF2AK2 (395147), domestic guinea pig Eif2ak2 (100717384) ...More
UniProtKB ID:
Gene ID:
- Human(5610) Summary: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- Mouse(19106) eukaryotic translation initiation factor 2-alpha kinase 2
- Rat(54287) eukaryotic translation initiation factor 2-alpha kinase 2
- Zebrafish(100001092) eukaryotic translation initiation factor 2-alpha kinase 2
- cow(347700) eukaryotic translation initiation factor 2-alpha kinase 2
- Horse(100147679) eukaryotic translation initiation factor 2-alpha kinase 2
- domestic cat(101082744) eukaryotic translation initiation factor 2-alpha kinase 2
- dog(611397) eukaryotic translation initiation factor 2-alpha kinase 2
- chicken(395147) eukaryotic translation initiation factor 2-alpha kinase 2
- domestic guinea pig(100717384) eukaryotic translation initiation factor 2-alpha kinase 2
- naked mole-rat(101724844) eukaryotic translation initiation factor 2-alpha kinase 2
- sheep(101121673) eukaryotic translation initiation factor 2-alpha kinase 2
- Domestic Rabbit(100009013) eukaryotic translation initiation factor 2-alpha kinase 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PKR (ET-20) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot
western blot
Anti-phospho-PKR (pThr258) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-PKR (pThr446) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-EIF2AK2 (Ab-451) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-PKR antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
esiRNA
Product Number
Description
Species