DUSP6
dual specificity phosphatase 6
Synonyms:
HH19, MKP3, PYST1
Species:
Human DUSP6 (1848), Mouse Dusp6 (67603), Rat Dusp6 (116663), Zebrafish dusp6 (353314), cow DUSP6 (515310), Horse DUSP6 (100051565), domestic cat DUSP6 (101097255), dog DUSP6 (482594), chicken DUSP6 (374272), naked mole-rat Dusp6 (101697963) ...More
UniProtKB ID:
Gene ID:
- Human(1848) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(67603) dual specificity phosphatase 6
- Rat(116663) dual specificity phosphatase 6
- Zebrafish(353314) dual specificity phosphatase 6
- cow(515310) dual specificity phosphatase 6
- Horse(100051565) dual specificity phosphatase 6
- domestic cat(101097255) dual specificity phosphatase 6
- dog(482594) dual specificity phosphatase 6
- chicken(374272) dual specificity phosphatase 6
- naked mole-rat(101697963) dual specificity phosphatase 6
- domestic guinea pig(100720904) dual specificity phosphatase 6
- sheep(101110315) dual specificity phosphatase 6
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DUSP6 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Monoclonal Anti-DUSP6 antibody produced in mouse, clone 3G2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-DUSP6 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-DUSP6 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-MPK-3 (DUSP6) Antibody, clone 5H6.1, clone 5H6.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
esiRNA
Product Number
Description
Species