DCC
deleted in colorectal carcinoma
Synonyms:
CRC18, CRCR1, IGDCC1, MRMV1
Species:
Human DCC (1630), Mouse Dcc (13176), Rat Dcc (25311), Zebrafish dcc (569360), dog DCC (483976), cow DCC (537176), Horse DCC (100054013), domestic cat DCC (101098832), domestic guinea pig Dcc (100712666), naked mole-rat Dcc (101705571)
UniProtKB ID:
Gene ID:
- Human(1630) Summary: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
- Mouse(13176) deleted in colorectal carcinoma
- Rat(25311) deleted in colorectal carcinoma
- Zebrafish(569360) deleted in colorectal carcinoma
- dog(483976) deleted in colorectal carcinoma
- cow(537176) deleted in colorectal carcinoma
- Horse(100054013) deleted in colorectal carcinoma
- domestic cat(101098832) deleted in colorectal carcinoma
- domestic guinea pig(100712666) deleted in colorectal carcinoma
- naked mole-rat(101705571) deleted in colorectal carcinoma
- sheep(101118654) deleted in colorectal carcinoma
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho DCC (Tyr1418), serum, from rabbit,
Species Reactivity
rat
Application
dot blot
immunofluorescence
western blot
immunofluorescence
western blot
Anti-DCC antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-DCC antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunofluorescence