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Merck

DACT1

dishevelled-binding antagonist of beta-catenin 1

Synonyms:
DAPPER, DAPPER1, DPR1, FRODO, HDPR1, THYEX3
Species:
Human DACT1 (51339), Mouse Dact1 (59036), Rat Dact1 (500666), Zebrafish dact1 (405799), chicken DACT1 (723789), domestic cat DACT1 (101098146), cow DACT1 (538778), dog DACT1 (100687551), sheep DACT1 (101116320), Domestic Rabbit DACT1 (100339172) ...More
UniProtKB ID:
Q9NYF0, A8MYJ2, Q86TY0
Gene ID:
  • Human(51339) Summary: The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
  • Mouse(59036) dapper homolog 1, antagonist of beta-catenin (xenopus)
  • Rat(500666) dishevelled-binding antagonist of beta-catenin 1
  • Zebrafish(405799) dapper homolog 1, antagonist of beta-catenin (xenopus)
  • chicken(723789) dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
  • domestic cat(101098146) dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
  • cow(538778) dishevelled-binding antagonist of beta-catenin 1
  • dog(100687551) dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
  • sheep(101116320) dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
  • Domestic Rabbit(100339172) dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
  • domestic guinea pig(100728819) dishevelled-binding antagonist of beta-catenin 1
  • naked mole-rat(101713951) dishevelled-binding antagonist of beta-catenin 1

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