CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
Synonyms:
CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1
Species:
Human CYP2D6 (1565), chicken CYP2D6 (417981), domestic cat CYP2D6 (100500743), sheep CYP2D6 (100568286)
UniProtKB ID:
Gene ID:
- Human(1565) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- chicken(417981) cytochrome P450, family 2, subfamily D, polypeptide 6
- domestic cat(100500743) cytochrome 2D6
- sheep(100568286) cytochrome P450 2D6
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CYP2D6 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-CYP2D6 antibody produced in mouse, clone 2C5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA