CDC45
cell division cycle 45
Synonyms:
CDC45L, CDC45L2, PORC-PI-1
Species:
Human CDC45 (8318), Mouse Cdc45 (12544), Rat Cdc45 (287961), Zebrafish cdc45 (406695), cow CDC45 (507122), chicken CDC45 (416776), dog CDC45 (486421), Horse CDC45 (100050871), domestic cat CDC45 (101097519), Thale Cress CDC45 (822101) ...More
UniProtKB ID:
Gene ID:
- Human(8318) Summary: The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- Mouse(12544) cell division cycle 45
- Rat(287961) cell division cycle 45
- Zebrafish(406695) CDC45 cell division cycle 45 homolog (S. cerevisiae)
- cow(507122) cell division cycle 45 homolog (S. cerevisiae)
- chicken(416776) cell division cycle 45 homolog (S. cerevisiae)
- dog(486421) cell division cycle 45 homolog (S. cerevisiae)
- Horse(100050871) cell division cycle 45 homolog (S. cerevisiae)
- domestic cat(101097519) cell division cycle 45 homolog (S. cerevisiae)
- Thale Cress(822101) cell division control protein 45
- naked mole-rat(101714952) cell division cycle 45
- domestic guinea pig(100728375) cell division cycle 45
- sheep(101121376) cell division cycle 45 homolog (S. cerevisiae)
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