CD46
CD46 molecule, complement regulatory protein
Synonyms:
AHUS2, MCP, MIC10, TLX, TRA2.10
Species:
Human CD46 (4179), Mouse Cd46 (17221), Rat Cd46 (29333), dog CD46 (609365), domestic cat CD46 (101094152), cow CD46 (280851), cow CD46 (616002), domestic guinea pig Cd46 (100135498), naked mole-rat Cd46 (101704640)
UniProtKB ID:
Gene ID:
- Human(4179) Summary: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
- Mouse(17221) CD46 antigen, complement regulatory protein
- Rat(29333) CD46 molecule, complement regulatory protein
- dog(609365) CD46 molecule, complement regulatory protein
- domestic cat(101094152) CD46 molecule, complement regulatory protein
- cow(280851) CD46 molecule, complement regulatory protein
- cow(616002) CD46 molecule, complement regulatory protein
- domestic guinea pig(100135498) CD46 antigen, complement regulatory protein
- naked mole-rat(101704640) CD46 molecule, complement regulatory protein
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CD46-APC antibody produced in mouse, clone MEM-258, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
bovine, human
Application
flow cytometry
Monoclonal Anti-CD46-PE antibody produced in mouse, clone MEM-258, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
bovine, human
Application
flow cytometry
Anti-CD46 Antibody, clone TRA-2-10, clone TRA-2-10, from mouse,
Species Reactivity
human
Application
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
Monoclonal Anti-CD46-FITC antibody produced in mouse, clone MEM-258, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
bovine, human
Application
flow cytometry
Monoclonal Anti-CD46 antibody produced in mouse, clone 1B6, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
western blot
Proteins
Product Number
Description
Species