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Merck

CBX3

chromobox homolog 3

Synonyms:
HECH, HP1-GAMMA, HP1Hs-gamma
Species:
Human CBX3 (11335), Mouse Cbx3 (12417), Rat Cbx3 (297093), naked mole-rat Cbx3 (101714000), domestic guinea pig Cbx3 (100714020), sheep CBX3 (101106931), chicken CBX3 (395355), dog CBX3 (482015), cow CBX3 (539788), domestic cat CBX3 (101099363)
UniProtKB ID:
Q13185, Q96CD7, Q99409, Q9BVS3, Q9P0Z6
Gene ID:
  • Human(11335) Summary: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
  • Mouse(12417) chromobox 3
  • Rat(297093) chromobox homolog 3
  • naked mole-rat(101714000) chromobox homolog 3
  • domestic guinea pig(100714020) chromobox homolog 3
  • sheep(101106931) chromobox homolog 3
  • chicken(395355) chromobox homolog 3
  • dog(482015) chromobox homolog 3
  • cow(539788) chromobox homolog 3
  • domestic cat(101099363) chromobox homolog 3

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Antibodies

Product Number
Description
Species Reactivity
Application
05-690
Anti-HP1γ Antibody, clone 42s2, clone 42s2, Upstate®, from mouse,
Species Reactivity
human, mouse
Application
ChIP
immunohistochemistry
western blot
WH0011335M1
Monoclonal Anti-CBX3 antibody produced in mouse, clone 1G12-1D9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
PLA0160
Rabbit anti-CBX3 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
MABE656
Anti-HP1γ Antibody, clone 14D3.1, clone 14D3.1, from mouse,
Species Reactivity
human, mouse, nonhuman primates, rat
Application
immunocytochemistry
western blot
07-972
Anti-phospho-HP1 γ (Ser83) Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
western blot