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Merck

ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

Synonyms:
ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
Species:
Human ATP2B4 (493), Mouse Atp2b4 (381290), Rat Atp2b4 (29600), Zebrafish atp2b4 (768304), chicken ATP2B4 (419934), dog ATP2B4 (403731), Horse ATP2B4 (100034081), cow ATP2B4 (282146), Horse ATP2B4 (100049920), domestic cat ATP2B4 (101101538) ...More
UniProtKB ID:
P23634, B1APW5, B1APW6, Q13450, Q13452, Q13455, Q16817, Q7Z3S1
Gene ID:
  • Human(493) Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(381290) ATPase, Ca++ transporting, plasma membrane 4
  • Rat(29600) ATPase, Ca++ transporting, plasma membrane 4
  • Zebrafish(768304) ATPase, Ca++ transporting, plasma membrane 4
  • chicken(419934) ATPase, Ca++ transporting, plasma membrane 4
  • dog(403731) ATPase, Ca++ transporting, plasma membrane 4
  • Horse(100034081) ATPase, Ca++ transporting, plasma membrane 4
  • cow(282146) ATPase, Ca++ transporting, plasma membrane 4
  • Horse(100049920) ATPase, Ca++ transporting, plasma membrane 4
  • domestic cat(101101538) ATPase, Ca++ transporting, plasma membrane 4
  • Domestic Rabbit(100353865) ATPase, Ca++ transporting, plasma membrane 4
  • domestic guinea pig(100337639) ATPase, Ca++ transporting, plasma membrane 4
  • naked mole-rat(101699650) ATPase, Ca++ transporting, plasma membrane 4

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Antibodies

Product Number
Description
Species Reactivity
Application
MABN1801
Anti-PMCA4b Antibody, clone JA3, clone JA3, from mouse,
Species Reactivity
chimpanzee, human
Application
ELISA
immunocytochemistry
immunohistochemistry
western blot