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Merck

APEX1

APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms:
APE, APE1, APEN, APEX, APX, HAP1, REF1
Species:
Human APEX1 (328), Mouse Apex1 (11792), Rat Apex1 (79116), Zebrafish apex1 (406730), cow APEX1 (281630), domestic cat APEX1 (101101318), dog APEX1 (482558), chicken APEX1 (100431102), Goat APEX1 (100860967), sheep APEX1 (101115462) ...More
UniProtKB ID:
P27695, Q969L5, Q99775
Gene ID:
  • Human(328) Summary: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
  • Mouse(11792) apurinic/apyrimidinic endonuclease 1
  • Rat(79116) APEX nuclease (multifunctional DNA repair enzyme) 1
  • Zebrafish(406730) APEX nuclease (multifunctional DNA repair enzyme) 1
  • cow(281630) APEX nuclease (multifunctional DNA repair enzyme) 1
  • domestic cat(101101318) APEX nuclease (multifunctional DNA repair enzyme) 1
  • dog(482558) APEX nuclease (multifunctional DNA repair enzyme) 1
  • chicken(100431102) APEX nuclease (multifunctional DNA repair enzyme) 1
  • Goat(100860967) APEX nuclease (multifunctional DNA repair enzyme) 1
  • sheep(101115462) APEX nuclease (multifunctional DNA repair enzyme) 1
  • naked mole-rat(101709711) APEX nuclease (multifunctional DNA repair enzyme) 1
  • domestic guinea pig(100719062) APEX nuclease (multifunctional DNA repair enzyme) 1

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Antibodies

Product Number
Description
Species Reactivity
Application
A2105
Anti-AP Endonuclease antibody, Mouse monoclonal, clone APEREF, purified from hybridoma cell culture,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
immunocytochemistry
microarray
western blot