AIRE
autoimmune regulator
Synonyms:
AIRE1, APECED, APS1, APSI, PGA1
Species:
Human AIRE (326), Mouse Aire (11634), Rat Aire (294328), Zebrafish aire (100007662), cow AIRE (784775), domestic cat AIRE (101091039), dog AIRE (487796), chicken AIRE (429666), naked mole-rat Aire (101725873), domestic guinea pig Aire (100729880)
UniProtKB ID:
Gene ID:
- Human(326) Summary: This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]
- Mouse(11634) autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
- Rat(294328) autoimmune regulator
- Zebrafish(100007662) autoimmune regulator
- cow(784775) autoimmune regulator
- domestic cat(101091039) autoimmune regulator
- dog(487796) autoimmune regulator
- chicken(429666) autoimmune regulator
- naked mole-rat(101725873) autoimmune regulator
- domestic guinea pig(100729880) autoimmune regulator
- sheep(101102698) autoimmune regulator
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-AIRE (Isoforms 1 and 2) (AB2) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot