Skip to Content
Merck

ABAT

4-aminobutyrate aminotransferase

Synonyms:
GABA-AT, GABAT, NPD009
Species:
Human ABAT (18), Mouse Abat (268860), Rat Abat (81632), Zebrafish abat (378968), cow ABAT (280969), Horse ABAT (100051470), domestic cat ABAT (101089064), dog ABAT (479856), chicken ABAT (416642), naked mole-rat Abat (101712584) ...More
UniProtKB ID:
P80404, A8K386, Q16260, Q8N5W2, Q96BG2, Q99800
Gene ID:
  • Human(18) Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(268860) 4-aminobutyrate aminotransferase
  • Rat(81632) 4-aminobutyrate aminotransferase
  • Zebrafish(378968) 4-aminobutyrate aminotransferase
  • cow(280969) 4-aminobutyrate aminotransferase
  • Horse(100051470) 4-aminobutyrate aminotransferase
  • domestic cat(101089064) 4-aminobutyrate aminotransferase
  • dog(479856) 4-aminobutyrate aminotransferase
  • chicken(416642) 4-aminobutyrate aminotransferase
  • naked mole-rat(101712584) 4-aminobutyrate aminotransferase
  • domestic guinea pig(100725419) 4-aminobutyrate aminotransferase
  • Goat(100861058) 4-aminobutyrate aminotransferase
  • sheep(101105462) 4-aminobutyrate aminotransferase

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
SAB2100006
Anti-ABAT antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, goat, guinea pig, human, mouse, rabbit, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Y0001400
Vigabatrin, European Pharmacopoeia (EP) Reference Standard,
Species
human
V-022
Vigabatrin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
1712001
Vigabatrin, United States Pharmacopeia (USP) Reference Standard,
Species
human
BP563
Vigabatrin, British Pharmacopoeia (BP) Reference Standard,
Species
human
V8261
(±)-Vigabatrin, ,
Species
human