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EGFR

epidermal growth factor receptor

Synonyms:
ERBB, ERBB1, HER1, PIG61, mENA
Species:
UniProtKB ID:
Gene ID:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor

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ELISA

Product Number
Description
Species
Cell-Based phospho-EGFR ELISA Sampler Kit, for detecting phospho-egfr(pTyr845), phospho-egfr(pTyr992), phospho-egfr(pTyr1068) and phospho-egfr in cultured cell lines,
Species
human
Human EGFR / ErbB1 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Tyrphostin AG 1478, ≥98%,
Species
human, mouse
SU 5416, ≥98% (HPLC),
Species
human, mouse
Genistein, synthetic, ≥98% (HPLC), powder,
Species
mouse, human, rat
Genistein, from Glycine max (soybean), ~98% (HPLC),
Species
mouse, human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-EGFRvIII Antibody, clone DH8.3, clone DH8.3, from mouse,
Species Reactivity
human
Application
ELISA
flow cytometry

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-EGFR antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-EGFR antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-EGFR (Ab-1172) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-phospho-EGFR (pTyr1092) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
PKI-166, ≥98% (HPLC),
Species
human
Tyrphostin 1, ≥98%,
Species
human
Gefitinib, ≥98% (HPLC),
Species
human
Erlotinib hydrochloride, ,
Species
human
DAPH, ≥98% (HPLC), solid,
Species
human

Proteins

Product Number
Description
Species
EGFR (T790M L858R) Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
human
EGFR/ErbB1 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Species
human
Epidermal Growth Factor Receptor human, buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry),
Species
human
Epidermal Growth Factor Receptor human, lyophilized powder, ≥15,000 units/mg protein (Bradford),
Species
human
EGF-receptor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Species
human