Skip to Content
Merck
  • A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment.

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment.

Nanoscale (2015-07-01)
Dennis B Pacardo, Bhanu Neupane, S Michaela Rikard, Yue Lu, Ran Mo, Sumeet R Mishra, Joseph B Tracy, Gufeng Wang, Frances S Ligler, Zhen Gu
PMID26122945
ABSTRACT

A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive dextran-azo compound for intracellular controlled drug release. The interaction of a AuNR complex with HeLa cells was facilitated via a folic acid targeting ligand as displayed in the dark-field images of cells. Enhanced anticancer efficacy was demonstrated through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics.

MATERIALS
Product Number
Brand
Product Description
33034
Sigma-Aldrich
L-Ascorbic acid, puriss. p.a., ACS reagent, reag. ISO, Ph. Eur., 99.7-100.5% (oxidimetric)
417939
Sigma-Aldrich
Dimethyl sulfoxide-d6, "100%", 99.96 atom % D, contains 0.03 % (v/v) TMS
302643
Sigma-Aldrich
Trypan Blue, ≥80% (HPLC), Dye content 60 %
452904
Sigma-Aldrich
Sodium borohydride solution, ~12 wt. % in 14 M NaOH
255564
Sigma-Aldrich
L-Ascorbic acid, ACS reagent, ≥99%
296147
Sigma-Aldrich
Dimethyl sulfoxide-d6, 99.9 atom % D, contains 0.03 % (v/v) TMS
227056
Sigma-Aldrich
N,N-Dimethylformamide, anhydrous, 99.8%
115533
Sigma-Aldrich
CDI, reagent grade
204390
Sigma-Aldrich
Silver nitrate, 99.9999% trace metals basis
185965
Sigma-Aldrich
Dimethyl sulfoxide-d6, 99.9 atom % D, contains 1 % (v/v) TMS
570672
Sigma-Aldrich
Dimethyl sulfoxide-d6, anhydrous, 99.9 atom % D
156914
Sigma-Aldrich
Dimethyl sulfoxide-d6, "100%", 99.96 atom % D
450561
Sigma-Aldrich
11-Mercaptoundecanoic acid, 95%
215511
Sigma-Aldrich
Sodium borohydride solution, 2.0 M in triethylene glycol dimethyl ether
D8418
Sigma-Aldrich
Dimethyl sulfoxide, for molecular biology
D9170
Sigma-Aldrich
Dimethyl sulfoxide, PCR Reagent
D4540
Sigma-Aldrich
Dimethyl sulfoxide, ≥99.5% (GC), suitable for plant cell culture
D2650
Sigma-Aldrich
Dimethyl sulfoxide, Hybri-Max™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%
T6146
Sigma-Aldrich
Trypan Blue, powder, BioReagent, suitable for cell culture
41639
Sigma-Aldrich
Dimethyl sulfoxide, BioUltra, for molecular biology, ≥99.5% (GC)
D2438
Sigma-Aldrich
Dimethyl sulfoxide, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma
85193
Sigma-Aldrich
Silver nitrate solution, 2.5 % (w/v) AgNO3 in H2O
D4551
Sigma-Aldrich
N,N-Dimethylformamide, for molecular biology, ≥99%
D1435
Sigma-Aldrich
Dimethyl sulfoxide, meets EP testing specifications, meets USP testing specifications
175943
Sigma-Aldrich
Dimethyl sulfoxide-d6, 99.5 atom % D
716731
Sigma-Aldrich
Dimethyl sulfoxide-d6, "Special HOH", ≥99.9 atom % D
95210
Sigma-Aldrich
L-Ascorbic acid, puriss. p.a., ≥99.0% (RT)
T8154
Sigma-Aldrich
Trypan Blue solution, 0.4%, liquid, sterile-filtered, suitable for cell culture