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Merck

Lipase catalysed synthesis of optically enriched alpha-haloamides.

Bioorganic & medicinal chemistry (2001-05-30)
A Azim, S K Sharma, C E Olsen, V S Parmar
PMID11377191
ABSTRACT

An efficient lipase catalysed synthesis of optically enriched alpha-halogenated amides with concomitant optical enrichment of the starting alpha-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.

MATERIALS
Product Number
Brand
Product Description
296856
Sigma-Aldrich
Diisopropyl ether, anhydrous, 99%, contains either BHT or hydroquinone as stabilizer
95251
Supelco
Diisopropyl ether, analytical standard
38270
Sigma-Aldrich
Diisopropyl ether, puriss. p.a., ≥98.5% (GC)
398276
Sigma-Aldrich
Diisopropyl ether, contains either BHT or hydroquinone as stabilizer, ACS reagent, ≥99.0%
673803
Sigma-Aldrich
Diisopropyl ether, contains either BHT or hydroquinone as stabilizer, ACS reagent, ≥99.0%
185302
Sigma-Aldrich
Diisopropyl ether, ReagentPlus®, 99%, contains either BHT or hydroquinone as stabilizer