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H7891

Sigma-Aldrich

Hexammine cobalt(III) chloride

for use in transformations, X-ray crystallography and NMR

Synonym(s):

Cobalt hexammine trichloride, Hexaamminecobalt trichloride

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About This Item

Linear Formula:
[Co(NH3)6]Cl3
CAS Number:
10534-89-1
Molecular Weight:
267.48
EC Number:
234-103-9
MDL number:
MFCD00036304
UNSPSC Code:
12352200
PubChem Substance ID:
24895812
NACRES:
NA.52

grade

for molecular biology

form

powder

storage temp.

room temp

SMILES string

N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Co+3]

InChI

1S/3ClH.Co.6H3N/h3*1H;;6*1H3/q;;;+3;;;;;;/p-3

InChI key

JXBGZYGSWFSYFI-UHFFFAOYSA-K

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General description

Hexammine cobalt(III) is considered an analog of fully solvated magnesium, capable of activating some enzymes that requires magnesium. It is useful in DNA condensation studies.

Application

Suitable for
  • DNA condensation studies
  • induction of transitions of DNA from B to A or Z forms
  • induction of nucleic acid crystal growth
  • stabilization of tertiary tRNA interactions
  • preparation of ligation buffer

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334,H351,H413

Hazard Classifications

Aquatic Chronic 4 - Carc. 2 - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christine C Conwell et al.
Biochemistry, 43(18), 5380-5387 (2004-05-05)
Millimolar concentrations of divalent cations are shown to affect the size of toroids formed when DNA is condensed by multivalent cations. The origins of this effect were explored by varying the order in which MgCl(2) was added to a series
Pinpinat Malaikaew et al.
Journal of photochemistry and photobiology. B, Biology, 103(3), 251-255 (2011-05-03)
In this study, a new small-molecule-based reagent was designed to recognize and bind to specific site in protein. A new pyrenyl probe, d-biotinyl-1(1-pyrene)methylamide (Py-biotin) was designed and synthesized by coupling of d-biotin to 1(1-pyrene)methylamine hydrochloride. Binding studies and site-specific photocleavage
T Allers et al.
Nucleic acids research, 28(2), e6-e6 (1999-12-22)
The Holliday junction is a central intermediate in genetic recombination. This four-stranded DNA structure is capable of spontaneous branch migration, and is lost during standard DNA extraction protocols. In order to isolate and characterize recombination intermediates that contain Holliday junctions
M C Whitby et al.
The Journal of biological chemistry, 273(31), 19729-19739 (1998-07-25)
The RecG protein of Escherichia coli is a junction-specific DNA helicase that drives branch migration of Holliday intermediates in genetic recombination and DNA repair. The reaction was investigated using synthetic X-junctions. RecG dissociates X-junctions to flayed duplex products, although DNA
Meredith Newby Lambert et al.
RNA (New York, N.Y.), 11(11), 1688-1700 (2005-10-26)
Helix (H)27 from Escherichia coli 16S ribosomal (r)RNA is centrally located within the small (30S) ribosomal subunit, immediately adjacent to the decoding center. Bacterial 30S subunit crystal structures depicting Mg(2+) binding sites resolve two magnesium ions within the vicinity of
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