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413A-1

Sigma-Aldrich

GLUT3 Rabbit Polyclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (413A-14)
vial of 0.5 mL concentrate (413A-15)
bottle of 1.0 mL predilute (413A-17)
vial of 1.0 mL concentrate (413A-16)
bottle of 7.0 mL predilute (413A-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

control

embryonal carcinoma, yolk sac tumor

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... SLC2A3(6515)

General description

Glucose transporter membrane 3 (GLUT3) is known as a solute carrier family 2 (facilitated glucose transporter) member 3 and represents a membrane bound glucose transporter. In one study scientists, using immunoprecipitation and western blot technologies, detected GLUT3 expression in spermatozoa of testis and brain but not in other types of tissue. In-house research via immunohistochemistry confirmed GLUT3 expression in testis/spermatozoa, but no GLUT3 was detected in brain. In a study conducted by Howitt BE et. al. anti-GLUT3 demonstrated membranous staining of seminoma cells in 44 cases (65%) of total 67 specimens. In addition, anti-GLUT3 labeled embryonal carcinoma (20/20) and yolk sac tumor (8/8) with 100% sensitivity.GLUT3 is not expressed in non-germ cell tumors such as leydig cell tumor and adenomatoid tumor.Spermatocytic seminoma, choriocarcinoma, and immature teratoma are also negative for GLUT3. Therefore, anti-GLUT3 is a very useful IHC marker to include in a panel for identification of germ cell tumors.

Quality


IVD
IVD
IVD
RUO

Linkage

GLUT3 Positive Control Slides, Product No. 413S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Brooke E Howitt et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(5), 401-407 (2013-01-25)
Testicular germ cell tumors (TGCT) are the most common type of testicular tumor and encompass different histologic types that greatly influence treatment and prognosis. Immunohistochemical studies may be required for accurate classification, particularly when these tumors present at extragonadal sites
R S Haber et al.
Endocrinology, 132(6), 2538-2543 (1993-06-01)
The tissue distribution of the GLUT3 glucose transporter protein was examined in human tissues using a rabbit antiserum directed against the C-terminal peptide sequence of human GLUT3. This anti-serum was shown to recognize the human GLUT3 protein in Chinese hamster

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