SCC255
WT-1 Mouse Brown Preadipocyte Cell Line
WT-1 mouse brown preadipocyte cell line is a useful model for studying adipogenesis and brown adipocyte biology.
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About This Item
UNSPSC Code:
41106514
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technique(s)
cell differentiation: suitable
General description
Obesity is a growing worldwide health epidemic that has spurred research into new avenues for treatment and control of metabolic disorders. Brown fat, a specialized adipose tissue characterized by increased energy expenditure, has emerged as an area of interest because manipulation of this tissue has potential to protect against diet-induced obesity by altering the balance of energy intake and consumption (1).
The WT-1 mouse immortalized brown preadipocyte cell line is derived from primary brown preadipocytes. WT-1 preadipocytes can be induced to differentiate into brown adipocytes upon treatment with induction and differentiation factors. WT-1 cells express the brown fat differentiation factor BMP7 and brown fat marker uncoupling protein-1 (UCP1) (3) and are a valuable model for investigation into mitochondrial physiology during adipogenesis. The WT-1 cell line has been used to develop 3D assays for adipose tissue (4) and is well suited for a range of questions in cellular metabolic research.
<bold>Source:</bold>
WT-1 cell line was established from primary brown pre-adipocytes isolated from newborn mouse pups and immortalized with Simian virus 40 (SV40) large T antigen (2).
Research Category:
Stem Cell Research
The WT-1 mouse immortalized brown preadipocyte cell line is derived from primary brown preadipocytes. WT-1 preadipocytes can be induced to differentiate into brown adipocytes upon treatment with induction and differentiation factors. WT-1 cells express the brown fat differentiation factor BMP7 and brown fat marker uncoupling protein-1 (UCP1) (3) and are a valuable model for investigation into mitochondrial physiology during adipogenesis. The WT-1 cell line has been used to develop 3D assays for adipose tissue (4) and is well suited for a range of questions in cellular metabolic research.
<bold>Source:</bold>
WT-1 cell line was established from primary brown pre-adipocytes isolated from newborn mouse pups and immortalized with Simian virus 40 (SV40) large T antigen (2).
Research Category:
Stem Cell Research
Cell Line Origin
Mouse, Adipocytes
Packaging
≥1X106 cells/vial
Storage and Stability
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Other Notes
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
Disclaimer
This product contains genetically modified organisms (GMO).
Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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