251600

Daidzein

Inactive analog of Genistein.

• Synonym(s): Daidzein, 4ʹ,7-Dihydroxyisoflavone, Casein Kinase II Inhibitor X
• Empirical Formula (Hill Notation): C₁₅H₁₀O₄
• CAS Number: 486-66-8
• Molecular Weight: 254.24
• MDL number: MFCD00016954
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
• InChI key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N

Description

General description

Inactive analog of Genistein (Cat. No. 345834). Blocks the G₁ phase of the cell cycle in Swiss/3T3 cells by inhibiting casein kinase II activity. Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC₅₀= 45 µM and 75 µM, respectively).

Inactive analog of genistein (Cat. No. 345834). Blocks the G₁ phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity. Inhibits epidermal growth factor (EGF) receptor autophosphorylation (IC₅₀ >300 µM). Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC₅₀= 45 µM and 75 µM, respectively).

Biochem/physiol Actions

Cell permeable: no

Primary Target
MiaPaC-2, PANC-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 45 µM, 75 µM for inhibiting the growth of MiaPaC-2 and PANC-1 cells, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. DMSO stock solutions are stable for up to 2 months at -20°C.

Other Notes

Guo, J-M., et al. 2004. World J. Gastroenterol.10, 860.
Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol.7, 637.
Akiyama, T., et al. 1987. J. Biol. Chem.262, 5592.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable