810130P
Avanti
16:0-06:0 NBD PC
Avanti Research™ - A Croda Brand 810130P, powder
Synonym(s):
1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine
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About This Item
Empirical Formula (Hill Notation):
C36H62N5O11P
CAS Number:
Molecular Weight:
771.88
UNSPSC Code:
12352211
NACRES:
NA.25
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810130P-1mg)
pkg of 5 × 1 mg (810130P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810130P
shipped in
dry ice
storage temp.
−20°C
General description
16:0-06:0 NBD PC (1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine) is a fluorescent analogue of phosphatidylcholine.
Application
16:0-06:0 NBD PC (1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine) has been used in NBD-phospholipid translocation assay. It may be used as a molecular fluorescent marker to label lipids during the friction tests, as substrate for enzyme substrate specificity determination and in the preparation of small unilamellar vesicles.
Biochem/physiol Actions
16:0-06:0 NBD PC (1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine) acts as a potential fluorescent probe. It is used for the quantification of the soluble and membrane-bound phospholipase A2 (PLA2) activity. 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) derivatives are widely used as fluorescent analogs of native lipids in biological and model membranes to study a variety of processes.
Packaging
5 mL Amber Glass Screw Cap Vial (810130P-1mg)
5 mL Amber Glass Screw Cap Vial (810130P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Effects of fluorescent probe NBD-PC on the structure, dynamics and phase transition of DPPC. A molecular dynamics and differential scanning calorimetry study
Loura L, et al.
Biochimica et Biophysica Acta - Biomembranes, 1778(2), 491-501 (2008)
In vitro analysis of the Staphylococcus aureus lipoteichoic acid synthase enzyme using fluorescently labeled lipids
Karatsa-Dodgson MW, et al.
Journal of Bacteriology, 192(20), 5341-5349 (2010)
The use of C6-NBD-PC for assaying phospholipase A2-activity: scope and limitations
Meyuhas D, et al.
Biochimica et Biophysica Acta, Lipids and Lipid Metabolism, 1124(3), 223-232 (1992)
Role of the biomolecular interactions in the structure and tribological properties of synovial fluid
Mirea DA, et al.
Tribology International, 59(3), 302-311 (2013)
Lenka Grycova et al.
PloS one, 7(10), e48437-e48437 (2012-11-03)
TRPV1 is a nonselective cation channel that integrates wide range of painful stimuli. It has been shown that its activity could be modulated by intracellular ligands PIP2 or calmodulin (CaM). The detailed localization and description of PIP2 interaction sites remain
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