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Merck

HSD3B2

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Synonyms:
HSD3B, HSDB, SDR11E2
Species:
Human HSD3B2 (3284), Mouse Hsd3b2 (15493), chicken HSD3B2 (396015), dog HSD3B2 (483146)
UniProtKB ID:
P26439, A2RRA5, Q16010, Q53GD4, Q6AI10, Q6LDB9, Q99890, Q9UD08
Gene ID:
  • Human(3284) Summary: The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(15493) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
  • chicken(396015) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
  • dog(483146) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1401187
Anti-HSD3B2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB1402232
Monoclonal Anti-HSD3B2 antibody produced in mouse, clone 1E8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
MABS2067
Anti-HSD3B2 Antibody, clone 6, clone 6, from mouse,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
SAB2108678
Anti-HSD3B2, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
SML0141
Trilostane, ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
EHU220251
MISSION® esiRNA, targeting human HSD3B2,
Species
human