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Merck

GRM6

glutamate receptor, metabotropic 6

Synonyms:
CSNB1B, GPRC1F, MGLUR6, mGlu6
Species:
UniProtKB ID:
Gene ID:
  • Human(2916) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]
  • Mouse(108072) glutamate receptor, metabotropic 6
  • Rat(24419) glutamate receptor, metabotropic 6
  • dog(481452) glutamate receptor, metabotropic 6
  • cow(529656) glutamate receptor, metabotropic 6
  • domestic cat(101097449) glutamate receptor, metabotropic 6
  • domestic guinea pig(100722389) glutamate receptor, metabotropic 6
  • naked mole-rat(101717017) glutamate receptor, metabotropic 6

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Small Molecule - Agonist

Product Number
Description
Species
D-2-Aminoadipic acid, ,
Species
rat
L-2-Aminoadipic acid, ≥98% (TLC),
Species
rat, human
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Species
human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(S)-AMPA, ≥97%,
Species
mouse, human, rat

Small Molecule - Antagonist

Product Number
Description
Species
D-2-Aminoadipic acid, ,
Species
rat
DL-2-Amino-3-phosphonopropionic acid, ,
Species
human
(S)-AMPA, ≥97%,
Species
mouse, human, rat
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GRM6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-GRM6 antibody produced in mouse, clone 1A11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-GRM6 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-Metabotropic Glutamate Receptor 6 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
Anti-MGLUR6 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GRM6,
Species
human
MISSION® esiRNA, targeting mouse Grm6,
Species
mouse