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  • LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

Proceedings of the National Academy of Sciences of the United States of America (2017-03-01)
Mingyu Gu, Dollie LaJoie, Opal S Chen, Alexander von Appen, Mark S Ladinsky, Michael J Redd, Linda Nikolova, Pamela J Bjorkman, Wesley I Sundquist, Katharine S Ullman, Adam Frost
PMID28242692
ABSTRACT

Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics in fission yeast, and surveillance of defective nuclear pore complexes in budding yeast. Here, we report that Lem2p (LEM2), a member of the LEM (Lap2-Emerin-Man1) family of inner nuclear membrane proteins, and the ESCRT-II/ESCRT-III hybrid protein Cmp7p (CHMP7), work together to recruit additional ESCRT-III proteins to holes in the nuclear membrane. In