- Basophils exhibit antibacterial activity through extracellular trap formation.
Basophils exhibit antibacterial activity through extracellular trap formation.
Allergy (2015-06-05)
S Yousefi, M Morshed, P Amini, D Stojkov, D Simon, S von Gunten, T Kaufmann, H-U Simon
PMID26043360
ABSTRACT
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Interleukin-3 human, IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sigma-Aldrich
Interleukin-3 human, IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sigma-Aldrich
Interleukin-3 human, IL-3, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Sigma-Aldrich
IL-3 human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture