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  • In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.

In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (1997-12-24)
K E Kinnamon, B T Poon, W L Hanson, V B Waits
ABSTRACT

Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective as the reference drug, nifurtimox. A major value of the present data is to demonstrate the refractoriness of the T. cruzi parasite against many of the drug standards that have known biological activity.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Protriptyline hydrochloride, ≥99% (TLC), powder