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[Neutrophils and hyaluronians in carcinogenesis].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (2013-07-26)
Marcin Tchórzewski, Adam Dziki, Henryk Tchórzewski
PMID23882925
ABSTRACT

Inflammatory processes involving polymorphonuclear leukocytes (PMNL) play an important role in cancer. PMNL can affect the formation and growth of the tumor. Cancer cells produce significant amounts of hyaluronans (HA), which pass into the extracellular space and are responsible for the inhibition of PMNL function through TLR4 receptor, and increase in the production of IL 10 the immunosuppressive cytokine as well as the other proinflammatory cytokines. HA supported the metastasis of cancer cells by binding to the CD44 receptor on endothelial cells. Increased PMNL--Lymphocyte ratio as a negative prognostic factor indicates also the important not defined role of PMNL in carcinogenesis.

MATERIALS
Product Number
Brand
Product Description
S0780000
Sodium hyaluronate, BRP, European Pharmacopoeia (EP) Reference Standard
H7630
Sigma-Aldrich
Hyaluronic acid sodium salt from bovine vitreous humor
40583
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 8,000-15,000
97616
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 15,000-30,000
H9390
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus zooepidemicus, bacterial glycosaminoglycan polysaccharide
53747
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, bacterial glycosaminoglycan polysaccharide
H5388
Sigma-Aldrich
Hyaluronic acid sodium salt from rooster comb, avian glycosaminoglycan polysaccharide
41897
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 1,000,000-1,250,000
42686
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 30,000-50,000
49775
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 1,200
51967
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 2,000,000-2,200,000
63357
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 1,500,000-1,750,000
73641
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 2,000,000-2,400,000
94137
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 10,000-30,000
06742
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 120,000-350,000
96144
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 70,000-120,000
08185
Sigma-Aldrich
Hyaluronic acid sodium salt from Streptococcus equi, mol wt 50,000-70,000