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M5883

Sigma-Aldrich

7-Methylguanosine 5′-diphosphate sodium salt

≥92.5%

Synonym(s):

7-Methyl-gdp, m7GDP

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10 MG
CZK 8,580.00
25 MG
CZK 23,100.00

CZK 8,580.00

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10 MG
CZK 8,580.00
25 MG
CZK 23,100.00

About This Item

Empirical Formula (Hill Notation):
C11H17N5O11P2 · xNa+
CAS Number:
104809-16-7
Molecular Weight:
457.23 (free acid basis)
MDL number:
MFCD00057869
UNSPSC Code:
41106305
PubChem Substance ID:
329818024
NACRES:
NA.51

CZK 8,580.00

Please contact Customer Service for Availability

biological source

synthetic (organic)

Quality Level

200

Assay

≥92.5%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

storage temp.

−20°C

SMILES string

[Na+].[Na+].C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3nc(N)nc([O-])c13

InChI

1S/C11H17N5O11P2.2Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(26-10)2-25-29(23,24)27-28(20,21)22;;/h3-4,6-7,10,17-18H,2H2,1H3,(H5-,12,13,14,19,20,21,22,23,24);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

InChI key

VSMXIKIFPKDZJA-IDIVVRGQSA-L

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This Item
I4375T9375A5763
7-Methylguanosine 5′-diphosphate sodium salt ≥92.5%

M5883

7-Methylguanosine 5′-diphosphate sodium salt

Inosine 5′-diphosphate sodium salt ≥96%

I4375

Inosine 5′-diphosphate sodium salt

Thymidine 5′-diphosphate sodium salt ≥96% (HPLC)

T9375

Thymidine 5′-diphosphate sodium salt

Adenosine 3′,5′-diphosphate disodium salt ≥96%

A5763

Adenosine 3′,5′-diphosphate disodium salt

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

assay

≥92.5%

assay

≥96%

assay

≥96% (HPLC)

assay

≥96%

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

solubility

water: 25 mg/mL, clear, colorless to very faintly yellow

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

7-Methylguanosine 5′-diphosphate (m7GDP) is derived when the human decapping Dcp2 enzyme cleaves the cap of the deadenylated mRNAs during the 5′–3′ mRNA decay pathway. [1]

Application

7-Methylguanosine 5′-diphosphate sodium salt has been used as a component of the elution buffer for the purification of 5’capped RNA.[2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCJ5789
    SLBQ2724V
    120M5071V
    SLBH3896V
    091M5051V

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    M Długosz et al.
    Journal of biochemical and biophysical methods, 51(2), 179-193 (2002-06-14)
    A method for extracting kinetic and optical parameters from progress curves for protein-ligand association, obtained by stopped-flow experiments, is described. The method is limited to one-step and two-step association kinetics, but it allows concentration of protein and offset of the
    Laurent Volpon et al.
    RNA (New York, N.Y.), 23(6), 927-937 (2017-03-23)
    The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are relatively well understood, the molecular
    Magdalena Lewdorowicz et al.
    RNA (New York, N.Y.), 10(9), 1469-1478 (2004-07-27)
    Leishmania and other trypanosomatids are early eukaryotes that possess unusual molecular features, including polycistronic transcription and trans-splicing of pre-mRNAs. The spliced leader RNA (SL RNA) is joined to the 5' end of all mRNAs, thus donating a 5' cap that
    Zhibo Zhang et al.
    Organic & biomolecular chemistry, 1(19), 3404-3409 (2003-10-31)
    The reactions of a 5'-cap model compound P1-(7-methylguanosine) P3-guanosine 5',5'-triphosphate, m7GpppG, were studied in the presence of three different macrocyclic amines (2-4) under neutral conditions. The only products observed in the absence of the macrocycles resulted from the base-catalysed imidazole
    Anna Wypijewska et al.
    Biochemistry, 51(40), 8003-8013 (2012-09-19)
    Decapping scavenger (DcpS) enzymes catalyze the cleavage of a residual cap structure following 3' → 5' mRNA decay. Some previous studies suggested that both m(7)GpppG and m(7)GDP were substrates for DcpS hydrolysis. Herein, we show that mononucleoside diphosphates, m(7)GDP (7-methylguanosine
    View All Related Papers

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