H5292

Cytochrome P450 2C19 I331V, human

recombinant, expressed in E. coli

• Synonym(s): Cytochrome P450, purified, soluble, CYP2C19 I331V, CYP2C19 Ile331Val
• CAS Number: 9035-51-2
• UNSPSC Code: 12352204
• NACRES: NA.54

Properties

• biological source: human
• Quality Level: 200
• recombinant: expressed in E. coli
• description: purified, soluble
• form: liquid
• specific activity: 12-110 units/mg protein
• mol wt: 54783.3 g/mol
• concentration: 3.2-25 mg protein/mL (protein); 50-150 nmol/mL (P450); 6-14 nmol/mg protein (specific content)
• NCBI accession no.: NP_00760.1
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... CYP2C19(1557)

Description

General description

Supplied as purified soluble proteins, rather than microsomal preparations.

Unit Definition

One unit will convert 1.0 nanomole of omeprazole (6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole) to 5-hydroxyomeprazole per minute at pH 7.4 at 37 °C.

Other Notes

Visit our drug metabolism resources: www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/cell-signaling-enzymes/xenobiotics.html

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): 320.0 °F - closed cup
• Flash Point(C): 160 °C - closed cup