G0657
GROα human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
MGSA, Melanoma Growth Stimulating Activity
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About This Item
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biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
1.0-4.0 ng/mL
mol wt
~7.9 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CXCL1(2919)
General description
GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), is a member of the small soluble chemokine protein family. It belongs to the C-X-C subfamily, which is comprised of 17 members. It contains a conserved glutamic acid-leucine-arginine (ELR) domain. This protein is expressed on stromal cells such as, endothelial cells, fibroblasts and blood-circulating cells.
Biochem/physiol Actions
GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), plays an essential role in neutrophil recruitment, and the initiation of angiogenesis. This gene is up-regulated in multiple cancer types such as, gastric cancer, renal cell carcinoma, prostate cancer and melanoma. The expression of this protein is also elevated in HER2 positive metastatic breast cancer. Its expression is increased in fibroblasts, which might be involved in breast tumor progression, and its stromal expression in breast cancer is linked to poor prognosis. This gene is also up-regulated in the aggressive phenotype of bladder cancer. Polymorphism rs4074 A in this gene is also associated with susceptibility to alcoholic cirrhosis.
Physical form
Lyophilized from a 0.2 μm filtered solution in 25% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.
Analysis Note
The biological activity is measured by its ability to induce chemotaxis of mouse BaF/3 cells transfected with hCXCR2.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
35.6 °F - (Acetonitrile)
Flash Point(C)
2.0 °C - (Acetonitrile)
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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An Zou et al.
BMC cancer, 14, 781-781 (2014-10-26)
CXCL1 is a chemotactic cytokine shown to regulate breast cancer progression and chemo-resistance. However, the prognostic significance of CXCL1 expression in breast cancer has not been fully characterized. Fibroblasts are important cellular components of the breast tumor microenvironment, and recent
Hans Dieter Nischalke et al.
PloS one, 8(11), e80848-e80848 (2013-11-22)
CXCL1 (CXC chemokine-ligand-1) is a ligand for CXC chemokine receptor 2 expressed on hepatic stellate cells (HSC). Thus, CXCL1 might contribute to HSC activation and fibrogenesis. In the present study, we investigated the influence of the CXCL1 rs4074 polymorphism on
Makito Miyake et al.
BMC cancer, 13, 322-322 (2013-07-03)
Chemokines, including chemokine (C-X-C motif) ligand 1 (CXCL1), may regulate tumor epithelial-stromal interactions that facilitate tumor growth and invasion. Studies have linked CXCL1 expression to gastric, colon and skin cancers, but limited studies to date have described CXCL1 protein expression
J M Schröder et al.
Journal of immunology (Baltimore, Md. : 1950), 139(10), 3474-3483 (1987-11-15)
A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC. Biologic activities of the purified cytokine
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