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Merck

WRN

Werner syndrome, RecQ helicase-like

Synonyms:
RECQ3, RECQL2, RECQL3
Species:
Human WRN (7486), Mouse Wrn (22427), Rat Wrn (290806), cow WRN (505061), sheep WRN (101106742), Domestic Rabbit WRN (100341925), naked mole-rat Wrn (101724469), domestic guinea pig Wrn (100719896), Zebrafish wrn (569495), chicken WRN (422505) ...More
UniProtKB ID:
Q14191, A1KYY9
Gene ID:
  • Human(7486) Summary: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
  • Mouse(22427) Werner syndrome homolog (human)
  • Rat(290806) Werner syndrome
  • cow(505061) Werner syndrome, RecQ helicase-like
  • sheep(101106742) Werner syndrome, RecQ helicase-like
  • Domestic Rabbit(100341925) Werner syndrome, RecQ helicase-like
  • naked mole-rat(101724469) Werner syndrome, RecQ helicase-like
  • domestic guinea pig(100719896) Werner syndrome, RecQ helicase-like
  • Zebrafish(569495) Werner syndrome
  • chicken(422505) Werner syndrome
  • domestic cat(101095574) Werner syndrome, RecQ helicase-like
  • dog(493997) Werner syndrome, RecQ helicase-like

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4504327
Anti-phospho-Werner Syndrome Helicase (pSer1141) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
SAB1404529
Monoclonal Anti-WRN, (C-terminal) antibody produced in mouse, clone 2F7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
WH0007486M9
Monoclonal Anti-WRN antibody produced in mouse, clone 3C11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
W0393
Anti-WRN antibody, Mouse monoclonal, clone 195C, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot