TTN
titin
Synonyms:
CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD
Species:
Human TTN (7273), Mouse Ttn (22138), Rat Ttn (84015), chicken TTN (424126), dog TTN (478820), domestic cat TTN (101080315), dog TTN (478819), domestic cat TTN (751825), naked mole-rat Ttn (101717863), Domestic Rabbit TTN (100008570) ...More
UniProtKB ID:
Gene ID:
- Human(7273) Summary: This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
- Mouse(22138) titin
- Rat(84015) titin
- chicken(424126) titin
- dog(478820) titin
- domestic cat(101080315) titin
- dog(478819) titin
- domestic cat(751825) titin
- naked mole-rat(101717863) titin
- Domestic Rabbit(100008570) titin
- domestic guinea pig(100722767) titin
- cow(540561) titin
- sheep(101122837) titin
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-TTN, (N-terminal) antibody produced in mouse, clone 8G9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Monoclonal Anti-TTN antibody produced in mouse, clone 6H5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-TTN antibody produced in mouse, clone 7D3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-TTN, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-Titin Antibody, clone 9B9, culture supernatant, clone 9B9, Chemicon®,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
PrEST Antigen TTN, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human