TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
Synonyms:
CD153, CD30L, CD30LG
Species:
Human TNFSF8 (944), Mouse Tnfsf8 (21949), Rat Tnfsf8 (683163), chicken TNFSF8 (378930), dog TNFSF8 (612608), domestic cat TNFSF8 (101099756), naked mole-rat Tnfsf8 (101720294), domestic guinea pig Tnfsf8 (100735796), cow TNFSF8 (574056), sheep TNFSF8 (101102699)
UniProtKB ID:
Gene ID:
- Human(944) Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
- Mouse(21949) tumor necrosis factor (ligand) superfamily, member 8
- Rat(683163) tumor necrosis factor (ligand) superfamily, member 8
- chicken(378930) tumor necrosis factor (ligand) superfamily, member 8
- dog(612608) tumor necrosis factor (ligand) superfamily, member 8
- domestic cat(101099756) tumor necrosis factor (ligand) superfamily, member 8
- naked mole-rat(101720294) tumor necrosis factor (ligand) superfamily, member 8
- domestic guinea pig(100735796) tumor necrosis factor (ligand) superfamily, member 8
- cow(574056) tumor necrosis factor (ligand) superfamily, member 8
- sheep(101102699) tumor necrosis factor (ligand) superfamily, member 8
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