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Merck

TEK

TEK tyrosine kinase, endothelial

Synonyms:
CD202B, TIE-2, TIE2, VMCM, VMCM1
Species:
Human TEK (7010), Mouse Tek (21687), Rat Tek (89804), Zebrafish tek (30747), dog TEK (403714), domestic cat TEK (101091977), chicken TEK (427368), cow TEK (280939), domestic guinea pig Tek (100713324), naked mole-rat Tek (101710501)
UniProtKB ID:
Q02763, A8K6W0, B4DH20, B4DHD3, D3DRK5, E7EWI2, Q5TCU2, Q8IV34
Gene ID:
  • Human(7010) Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
  • Mouse(21687) endothelial-specific receptor tyrosine kinase
  • Rat(89804) TEK tyrosine kinase, endothelial
  • Zebrafish(30747) TEK tyrosine kinase, endothelial
  • dog(403714) TEK tyrosine kinase, endothelial
  • domestic cat(101091977) TEK tyrosine kinase, endothelial
  • chicken(427368) TEK tyrosine kinase, endothelial
  • cow(280939) TEK tyrosine kinase, endothelial
  • domestic guinea pig(100713324) TEK tyrosine kinase, endothelial
  • naked mole-rat(101710501) TEK tyrosine kinase, endothelial

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ELISA

Product Number
Description
Species
RAB1930
Rat Tie-2 ELISA, for serum, plasma and cell culture supernatants,
Species
rat
RAB0457
Human Tie-2 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human
RAB1002
Phosphotyrosine TEK / Angiopoietin-1 Receptor ELISA Kit, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB4502942
Anti-TIE2, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
07-1431
Anti-Tie-2 Antibody, NT, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse, rat
Application
western blot
05-584
Anti-Tie2/TEK Antibody, clone Ab33, clone Ab33, Upstate®, from mouse,
Species Reactivity
human, mouse, pig, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
ZRB1645
Anti-Tie-2 Antibody, clone 1C5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, human, monkey, mouse, rat
Application
affinity binding assay
immunocytochemistry
western blot
SAB4301315
Anti-phospho-TIE2 (pTyr992) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
C8863
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
14-540-M
Tie2 Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Tie2 residues 771-end, for use in Kinase Assays.,
Species
human