SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Synonyms:
EL2, HPP, HS3, SPH3, SPTA
Species:
Human SPTA1 (6708), Mouse Spta1 (20739), Rat Spta1 (289257), domestic cat SPTA1 (101097298), Horse SPTA1 (100056575), dog SPTA1 (488616), domestic guinea pig Spta1 (100722803), naked mole-rat Spta1 (101706547), cow SPTA1 (505122), sheep SPTA1 (101112688)
UniProtKB ID:
Gene ID:
- Human(6708) Summary: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
- Mouse(20739) spectrin alpha, erythrocytic 1
- Rat(289257) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- domestic cat(101097298) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- Horse(100056575) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- dog(488616) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- domestic guinea pig(100722803) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- naked mole-rat(101706547) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- cow(505122) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- sheep(101112688) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SPTA1, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-Spectrin (α and β) antibody produced in mouse, clone SB-SP1, ascites fluid,
Species Reactivity
human
Application
immunofluorescence
microarray
western blot
microarray
western blot
Anti-Spectrin antibody produced in rabbit, whole antiserum,
Species Reactivity
human
Application
western blot
Proteins
Product Number
Description
Species