REN
renin
Synonyms:
HNFJ2
Species:
Human REN (5972), Rat Ren (24715), cow REN (280909), sheep REN (443310), naked mole-rat Ren (101725618), domestic guinea pig Ren (100724037), fruit fly ren (44122), domestic cat REN (101081695), dog REN (403838), Zebrafish ren (405786)
UniProtKB ID:
Gene ID:
- Human(5972) Summary: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
- Rat(24715) renin
- cow(280909) renin
- sheep(443310) renin
- naked mole-rat(101725618) renin
- domestic guinea pig(100724037) renin
- fruit fly(44122) renegade
- domestic cat(101081695) renin
- dog(403838) renin
- Zebrafish(405786) renin
- chicken(431167) renin
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