PCGF2
polycomb group ring finger 2
Synonyms:
MEL-18, RNF110, ZNF144
Species:
Human PCGF2 (7703), Mouse Pcgf2 (22658), Rat Pcgf2 (287662), domestic guinea pig Pcgf2 (100719492), naked mole-rat Pcgf2 (101721189), cow PCGF2 (505147), sheep PCGF2 (101120343), chicken PCGF2 (425919), domestic cat PCGF2 (101087022), Horse PCGF2 (100055282)
UniProtKB ID:
Gene ID:
- Human(7703) Summary: The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
- Mouse(22658) polycomb group ring finger 2
- Rat(287662) polycomb group ring finger 2
- domestic guinea pig(100719492) polycomb group ring finger 2
- naked mole-rat(101721189) polycomb group ring finger 2
- cow(505147) polycomb group ring finger 2
- sheep(101120343) polycomb group ring finger 2
- chicken(425919) polycomb group ring finger 2
- domestic cat(101087022) polycomb group ring finger 2
- Horse(100055282) polycomb group ring finger 2
- dog(491035) polycomb group ring finger 2
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