FKBP1A
FK506 binding protein 1A, 12kDa
Synonyms:
FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE
Species:
Human FKBP1A (2280), Mouse Fkbp1a (14225), Rat Fkbp1a (25639), chicken FKBP1A (374233), domestic cat FKBP1A (101100379), cow FKBP1A (614795), dog FKBP1A (100686033), sheep FKBP1A (101105938), Domestic Rabbit FKBP1A (100328942), domestic guinea pig Fkbp1a (100713967)
UniProtKB ID:
Gene ID:
- Human(2280) Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
- Mouse(14225) FK506 binding protein 1a
- Rat(25639) FK506 binding protein 1a
- chicken(374233) FK506 binding protein 1A, 12kDa
- domestic cat(101100379) FK506 binding protein 1A, 12kDa
- cow(614795) FK506 binding protein 1A, 12kDa
- dog(100686033) FK506 binding protein 1A, 12kDa
- sheep(101105938) FK506 binding protein 1A, 12kDa
- Domestic Rabbit(100328942) FK506 binding protein 1A, 12kDa
- domestic guinea pig(100713967) FK506 binding protein 1A, 12kDa
- naked mole-rat(101702830) FK506 binding protein 1A, 12kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-FKBP1A antibody produced in mouse, clone 1E5-A12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-FKBP1A (53-66) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Tacrolimus for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Proteins
Product Number
Description
Species