FGFR2
fibroblast growth factor receptor 2
Synonyms:
BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
Species:
Human FGFR2 (2263), Mouse Fgfr2 (14183), Rat Fgfr2 (25022), Zebrafish fgfr2 (352940), Horse FGFR2 (100033956), domestic cat FGFR2 (101095198), cow FGFR2 (404193), chicken FGFR2 (396259), dog FGFR2 (415125), domestic guinea pig Fgfr2 (100379152) ...More
UniProtKB ID:
Gene ID:
- Human(2263) Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
- Mouse(14183) fibroblast growth factor receptor 2
- Rat(25022) fibroblast growth factor receptor 2
- Zebrafish(352940) fibroblast growth factor receptor 2
- Horse(100033956) fibroblast growth factor receptor 2
- domestic cat(101095198) fibroblast growth factor receptor 2
- cow(404193) fibroblast growth factor receptor 2
- chicken(396259) fibroblast growth factor receptor 2
- dog(415125) fibroblast growth factor receptor 2
- domestic guinea pig(100379152) fibroblast growth factor receptor 2
- naked mole-rat(101709077) fibroblast growth factor receptor 2
- sheep(443548) fibroblast growth factor receptor 2
- Domestic Rabbit(100009417) fibroblast growth factor receptor 2
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-FGFR2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-FGFR2 antibody produced in mouse, clone 1G3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
FGFR2 Protein, active, 10 µg, Active, N-terminal, His6-tagged, recombinant, human FGFR2, amino acids 456-770, for use in Kinase Assays.,
Species
human