DUX4

double homeobox 4

Synonyms:

DUX10

Species:

UniProtKB ID:

Gene ID:

Human(22947) Summary: This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of this gene from standard cDNA libraries, however, RT-PCR and in vitro expression experiments indicate that the ORF is transcribed. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, May 2013]
dog(491532) uncharacterized LOC491532

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Product Number

Description

Species Reactivity

Application

Monoclonal Anti-DUX4 antibody produced in mouse, clone P2B1, 1 mg/mL, purified immunoglobulin,

Species Reactivity

human

Application

immunofluorescence
immunohistochemistry
western blot

Anti-Dux4 Antibody, clone 9A12, clone 9A12, from mouse,

Species Reactivity

human

Application

electrophoretic mobility shift assay
immunocytochemistry
immunoprecipitation (IP)
western blot