CRK
v-crk avian sarcoma virus CT10 oncogene homolog
Synonyms:
CRKII, p38
Species:
Human CRK (1398), Mouse Crk (12928), Rat Crk (54245), domestic guinea pig Crk (100718486), naked mole-rat Crk (101717585), sheep CRK (101115380), Zebrafish crk (445234), fruit fly crk (248187), domestic cat CRK (101086100), cow CRK (512841) ...More
UniProtKB ID:
Gene ID:
- Human(1398) Summary: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
- Mouse(12928) v-crk sarcoma virus CT10 oncogene homolog (avian)
- Rat(54245) v-crk avian sarcoma virus CT10 oncogene homolog
- domestic guinea pig(100718486) v-crk sarcoma virus CT10 oncogene homolog (avian)
- naked mole-rat(101717585) v-crk sarcoma virus CT10 oncogene homolog (avian)
- sheep(101115380) v-crk sarcoma virus CT10 oncogene homolog (avian)
- Zebrafish(445234) v-crk sarcoma virus CT10 oncogene homolog (avian)
- fruit fly(248187) crooked setae
- domestic cat(101086100) v-crk sarcoma virus CT10 oncogene homolog (avian)
- cow(512841) v-crk sarcoma virus CT10 oncogene homolog (avian)
- dog(100684309) v-crk sarcoma virus CT10 oncogene homolog (avian)
- chicken(417553) v-crk sarcoma virus CT10 oncogene homolog
- fruit fly(43775) CG1587 gene product from transcript CG1587-RD
- Thale Cress(828087) actin related protein 2/3 complex, subunit 5
- Thale Cress(824217) CDPK-related kinase
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